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Humulene, sometimes referred to as alpha-caryophyllene or -carophyllene, alpha humulene or -humulene, is a specific type of terpene found on the flower bud, in the trichomes, and on the leaves of certain varieties of cannabis (and other) plants. -caryophyllene (BCP) is a plant compound, a member of bicyclic sesquiterpene.In nature, it mainly occurs as trans-caryophyllene ((E)-BCP) mixed with small amounts of its isomers, (Z)--caryophyllene (iso-caryophyllene) and -humulene (-caryophyllene), as well as its oxidation derivative-caryophyllene oxide (BCPO) (Fig. Like beta-caryophyllene, humulene is a cannabinoid and sesquiterpene, although it does not contain a cyclobutane ring. Humulene is a terpene commonly found in cannabis and its plant family cousin, hops. Two major . A non-cytotoxic concentration of beta-caryophyllene significantly increased the anticancer activity of alpha-humulene and isocaryophyllene on MCF-7 cells: alpha-humulene or isocaryophyllene alone (32 microg mL(-1)) inhibited cell growth by about 50% and 69%, respectively, compared with 75% and 90% when combined with 10 microg mL(-1) beta . Humulene is also commonly found in ginseng, sage, ginger, and of course cannabis. Rare profiles with a variety of terpenes comprise exotic cannabis chemovars also known as strains. It can also be found in cloves, ginseng, and basil. Humulene can be found in Vietnamese coriander, cloves, sage and black pepper. a-humulene imparts an earthy aroma in cannabis, whereas b-caryophyllene leaves more of a spicy, peppery note in the air as you pull a fresh bud apart with your fingers. 801 The inhibitory effects of -caryophyllene, -caryophyllene oxide and -humulene on the activities of the main drug-metabolizing enzymes in rat and human liver in vitro - PubMed (nih.gov) Abstract Sesquiterpenes, the main components of plant essential oils, are often taken in the form of folk medicines and dietary supplements. These earthy notes are very evident when you drink a glass of beer. daSilvaGomesa M.V., daSilvaa J.D., Ribeiroab A.F., Cabrala L.M. Not to be confused with -caryophyllene, which is a close "relative". Humulene, also known as -caryophyllene, is a ring-opened isomer of -caryophyllene, which is notably lacking in CB2 activity. The human body's endocannabinoid system contains a vast network of receptors located throughout the body. Humulene: The Anti-Inflammatory Terpene. Humulene is closely related to the more common terpene, b-caryophyllene. 28. Humulene can be used to protect the health of both plants and animals. In Part 2, we explored Myrcene, Humulene, and Limonene. In Cannabis Terpenes and Their Effects, Part 1, we looked at Phellandrene, Linalool, and Pinene. Humulene , which is known by other designations as -humulene or -caryophyllene, is a ring-opened isomer of -caryophyllene oxide . It has woody Oceanic and watery. As such it is fairly common in chemovars, though its concentration may vary. But it can be found in both indica and sativa strains, and there are plenty of hybrid strains that have high levels of caryophyllene. Acheflan herbal medicine is the first medicine developed and produced in Brazil using Cordia verbenacea DC., Boraginaceae, essential oil as a constituent.C. Cannabis appears to produce humulene when Afghanistan genetics cross into various OG Kush cultivars. It can act as an anti-inflammatory, sedative, or anti-nausea medication. All these findings indicate that alpha-humulene and (-)-trans-caryophyllene, derived from the essential oil of C. verbenacea, might represent important tools for the . It is a known Chinese alternative medicine that is often combined with beta-caryophyllene to fight infections. In cannabis, it is found most often in sativa strains. It is obtained from the flowers and stems of cloves. Among Tilray's crop, high-humulene varieties include Pink Kush, Sour Diesel, and Skywalker OG. This terpene was once believed to be the same type of terpene as another compound that has an identical molecular formula: beta-caryophyllene (-caryophyllene). We'd like to introduce you to three of those primary and secondary terpenes: humulene, caryophyllene, and trans-nerolidol. Beta-caryophyllene, often called simply caryophyllene, is a terpene that has a spicy, peppery scent with hints of cinnamon. Alpha humulene (alpha caryophyllene) is mostly found in many types of essential oils like clove oil. The researchers reported that these molecules "were more effective in [the] reduction ofhuman breast cancer cell line proliferation [when acting together] than when used separately." Caryophyllene (or -Caryophyllene) is a spicy, peppery terpene found in many different edible plants. It has a variety of medical properties. Use of -Caryophyllene -Humulene is a main constituent of Tanacetum vulgare L. (Asteraceae) essential oil with anti-inflammation (IC50=152 g/mL . All mass spectra in this site (plus many more) are available from the NIST/EPA/NIH Mass Spectral Library. Albeit less common, some exotic cannabis genetics and at least one traditional cultivar can produce humulene. Its chemical name is C15H24. Humulene: A Caryophyllene Isomer Humulene, also known as alpha-caryophyllene, is an herbaceous terpene that is used in traditional Eastern medicine as well as modern biomedical research. Humulene, also known as humulene or -caryophyllene is a naturally occurring monocyclic sesquiterpene characteristic of Humulus lupulus [56]. Humulene, also known as -caryophyllene, offers a subtle woody, earthy, and spicy notes partly responsible for the unique scent of cannabis. Caryophyllene differs from myrcene and pinene in that it has three isoprene units instead of two. Humulene is named for hops, which has the Latin name Humulus lupulus. It is usually found as a mixture with isocaryophyllene (the cis double bond isomer) and -humulene (obsolete name: -caryophyllene), a ring-opened isomer. Beta-caryophyllene is responsible for producing the sweet and spicy aromatic profiles of black pepper, cinnamon, and cloves. The three main medical benefits of terpenes are its anti-cancer properties, the reduction of systemic inflammation, and its significant role as an analgesic (pain killer). Humulene Humulene was the first terpene found in hops. Caryophyllene, more formally known as beta or b caryophyllene, is an extremely common terpene found in cannabis that is known for its herbal spiciness with hints of wood. Humulene was labeled "-caryophyllene," and the other was referred to as "-caryophyllene." However, experts later realized that the two terpenes were isomers of one another. Scientists first isolated humulene from the essential oil of this plant. In pre-clinical studies, -caryophyllene, -humulene, and eugenol were shown to have anti-inflammatory activity [28, 29], and -caryophyllene has been shown to act as an agonist of the CB2 . Sesquiterpenes such as caryophyllene, humulene, and cardinene are heavy terpenes (again, think weight) that are responsible for a wide range of pungent scents including diesel fuel, . It is a mixture of various aromatic plants. Caryophyllene is a terpene, so it can't be a sativa or an indica. Higher levels of humulene tend to be found in noble hops compared to other varieties so while farnesene levels indicate noble hop like characteristics, humulene levels seem also to be in part responsible. Both humulene ( 44) and -caryophyllene (45) are widely occurring sesquiterpenes found in numerous higher plants. 40. }, doi = {10.1016/0003-9861 (84)90513 . What terpene helps with nausea? Coincidentally, cannabis and hops belong to the same plant genus. Early research has shown humulene to be anti-proliferative, meaning it prevents cancer cells from growing. BETA-CARYOPHYLLENE. Hops and cannabis are both in the taxonomic family Cannabaceae, and humulene plays a big role in providing the same aromatic notes to both species of plants. ring opening metathesis polymerization of the natural sesquiterpenes caryophyllene and humulene, optionally complemented by exhaustive post-polymerization hydrogenation, yields non-crosslinked linear polymers with unprecedented microstructures reflecting the specific scaffolds of the feedstocks and with low glass transition temperatures in the Beta-caryophyllene (b-caryophyllene or BCP) is one of the most abundant terpenes found in cannabis. Now let's take a look at Ocimene, Terpinolene, and -Caryophyllene to finish the series out. Humulene, also known as alpha-caryophyllene or a-humulene, derives its name from the Latin Humulus Lupulus, which . Alpha-humulene is the renamed alpha-caryophyllene. Humulene has the chemical formula CH. Terpene profiles will soon be commonplace among cannabis consumers. Hops essential oil contains as much as 40% humulene. A multitude of scientific studies have proven that its therapeutic properties include reducing inflammation, relieving pain, and suppressing appetite. Humulene, also known as -humulene or -caryophyllene, is a naturally occurring monocyclic sesquiterpene (C 15 H 24 ), containing an 11-membered ring and consisting of 3 isoprene units containing three nonconjugated C=C double bonds, two of them being triply substituted and one being doubly substituted. However, each terpene that fits into the sesquiterpene . Beta-caryophyllene is often compared to the herbaceous terpene alpha-caryophyllene or humulene. While both terpenes are present in hops, they share a similar molecular formation; humulene is an isomer of caryophyllene. Due to a different double bond in their [] The present study is designed to find out if sesquiterpenes, -humulene (HUM), valencene (VAL), -caryphyllene-oxide (CAO) and trans-nerolidol (NER), are able to improve the antiproliferative effect of classical cytostatic drugs, 5-fluorouracil (FU) and oxaliplatin (1,2-diaminocyclohexaneoxalato-platinum, OxPt), in colon cancer cell lines Caco-2 and SW-620. These six impart the marijuana-ness of the delicious aromas that all cannabis shares. Humulene holds many of the same characteristics as beta-caryophyllene (a terpene in FOCUS we'll discuss in Terpenes 101 Part III) and is known in many scientific circles as alpha-caryophyllene. Higher levels of humulene tend to be found in noble hops compared to other varieties so while farnesene levels indicate noble hop like characteristics, humulene levels seem also to be in part responsible. For this reason, humulene is also sometimes known as alpha-caryophyllene. Humulene and farnesene are more common in hops than cannabis, yet both terpenes are present in some cuts of PB MAC.

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